Cultivation Process of Blazei-MRL™
MRL Ltd.´s Agaricus blazei powder contains both mycelium and primordia (young fruit body) cultivated into a biomass that is grown on a sterilised (autoclaved) substrate.
This cultivation process ensures the powder is free from contamination by other fungi and that pesticides and heavy metals are absent.
The cultivation system is proprietary, allowing for standardised production of Agaricus blazei. The powder biomass is then sealed in plastic containers.
The Blazei-MRL biomass contains mycelium and primordia (young fruiting body) of the respective mushroom. In comparison to Agaricus extracts, biomass has the advantage of no unwanted shift of effect which happens with extracts or concentrates, including lyophilisation, and thus the activity of the product corresponds with the source mushroom, while being further intensified by utilizing the entire mycelium.
Mycelium biomass of mushrooms offers a mixture of many co-operating and co-related healthful bioavailable ingredients prepared by nature itself – it is thus a truly pure natural product.
Mushrooms spend more than 90% of their life cycle in the mycelium. Since mushrooms cannot produce their own energy through photosynthesis, the mycelium must be able to actively obtain or produce extracellular compounds and metabolites that promote the longevity and vitality of the living mushroom. These properties lie behind the high enzymatic activity of the mycelium, which stays preserved in the carefully processed MRL products.
Manufacturing Process of Blazei-MRL™
The Agaricus blazei is processed under the same rigorously controlled conditions that are applied to the manufacture of a conventional pharmaceutical. This ensures that each tablet contains 500 mg of the standardised Agaricus product.
The tablets are film coated to protect them from moisture, thus preserving the quality of the product and ensuring a long shelf life.
After passing quality control testing the tablets are released for use. The choice of additives used in manufacture renders these tablets suitable for Kosher or vegetarian use.
The fungal biomass Agaricus blazei that comprises Blazei-MRL is certified 100% Organic in the United States by Quality Assurance International (Certificate No. 103491-A).
In December of 2005, MRL powder gained EU organic certification in accordance with EU Council Regulation (EEC) No. 2092/91 by Quality Assurance International (Certificate No. 105493-A).
Chemical and Biological Properties *
Agaricus blazei** Content per gram of biomass (in the absence of Proteolytic Enzymes)
|Cytochrome P-450||0.45 nmoles|
|Cytochrome P-450 reductase||8.90 mU|
|Protein bound polysacharides||87.6 mg|
|Reducing sugars||20.38 mg|
|Superoxide dismutase (SOD)||275.0 U|
Blazei-MRL –Enzyme activity (U/500 mg Biomass)***
|Superoxide dismutase (SOD)||143.5 103 U|
|NADPH (Cyt. "P-450" reductase)||7,500 uM|
|GSH Reductase||510.0 U|
*This statement has not been evaluated by the Food and Drug Adminstration. The product is not intended to diagnose, treat, cure or prevent any disease.
** Agaricus blazei supplied by Mycology Research Laboratories Ltd.
*** Cornelius C. e tal “ Comparative Enzyme Analysis of Polyporus umbellatus, Agaricus blazei, Pleurotus osteratus and Hericium erinaceus” pp 5, Clinical Journal of Mycology, 7;2009 Vol II.