1) Institute of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, Portugal, Portugal
2) CNC.IBILI - University of Coimbra, Portugal
3) CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
4) III-Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Portugal
5) Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country (UPV/EHU) Leioa, Spain
6) Ikerbasque Basque Foundation for Science, Bilbao, Bizkaia, Spain
7) Faculty of Pharmacy, University of Coimbra, Portugal
8) Ministry of Education, Maputo, Mozambique
9) Faculty of Veterinary Medicine, Lisbon University, Lisbon, Portugal, Portugal
10) Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Italy
11) Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Portugal
The poster was presented on July 3rd 2018 at the World Congress of Pharmacognosy 2018 in Kyoto Japan with the following conclusions:
1) CV biomass oral administration promotes a significant increase in dendritic length and branching and total dendritic volume of immature neurons, suggesting a positive effect in the hippocampal neurogenic reserve.
2) Increase of β-catenin levels both in nucleus and cytoplasm of DG immature neurons, suggests that Wnt/β-catenin signalling plays an important role in the CV positive effect on the dendritic complexity of hippocampal newly-generated neurons.
3) The so far unexplored neurogenic potential of CV supplementation emerges as a possible preventive strategy for different neurological conditions.
Clinical Articles
The following section outlines the clinical papers, posters and proposals that refer to the clinical use of MRL mushroom nutrition products. This information is for healthcare practitioners only and should not be provided to members of the general public.
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Clinical articles
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Bioaccessibility and Bioavailability of Bioactive Compounds from Mushroom Biomass Following in vitro Gastrointestinal Digestion presented at the CIPCA 2025 X International Conference on Food Proteins and Collides June 16-18, 2025 in Porto Portugal.
Helena Araújo-Rodrigues, Manuela Machado, João B. Relvas , Freni K. Tavaria, Manuela Pintado -
Neuroprotective Effects of Mushroom Biomass: Impact of Serum-Available and Gut Microbiota Metabolites in Caenorhabditis elegans Models of Alzheimer’s Disease. Presented on June 13th at the XXIII EURO FOODCHEM 2025 Conference in Bratislava, Slovakia
Helena Araújo-Rodrigues,Lidia Garzón-García, João B. Relvas, Freni K. Tavaria, Celestino Santos-Buelga, Ana M. González-Paramás, and Manuela E. Pintado -
Chemical Composition of Trametes versicolor, Hericium erinaceus, and Pleurotus ostreatus Mushroom Biomass: Deciphering their Rich α-glucan Composition and Nutritional Value
Helena Araújo-Rodrigues, Manuela Amorim, Clara Sousa, Ana Sofia Salsinha, Sara Marçal, Victor de Freitas, Joao Bettencourt Relvas, Freni K. Tavaria,Manuela E. Pintado. Journal of Food Composition and Analysis 143 (2025) 107612. -
Supporting Neurologic Health with Mushroom Nutrition
Victoria Bell, Palmen Dimitrov and Tito Fernandes