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December'13

In this issue, Prof. Amin Karmali compares in vitro the impact of proteolytic enzymes on the beta-glucan content, enzyme content and secondary metabolite content between a biomass form of Ganoderma lucidum (Reishi) versus an extracted form of Ganoderma lucidum. Various forms of Beta 1,3 -1,6 glucan activities are measured, such as water soluble fraction, hot water fraction, NaOH fraction, KOH fraction and HCI fraction. In terms of enzymes, measurements, super-oxide dismutase activity (SOD), peroxidase activity, Glucoamylase/Beta-glucanasase activity, Glucose 2-oxdase activity, Cytochrome “P-450”, Cytochrome P 450 reductase were taken in the absence of proteolytic enzymes and in the presence of proteolytic enzymes.

A copy of Professor Todor Chernev´s poster presentation entitled “Coriolus-MRL supplementation in patients infected with low-risk and high-risk HPV subtypes - Bulgarian experience. The original poster presentation on the use of Coriolus-MRL in two separate studies (100 patients and 200 patients respectively) reinforces the original clinical work by Dr. Silva Couto in which Coriolus-MRL is a useful tool for gynecologists when working with HPV LSIL patients with High risk viral subtypes.

Presented is an English translation of a 2008 Bulgarian Medline article on Coriolus-MRL by Dr. Yuliyana Bogdanova (PhD) from the Bulgarian Institute of Botany, Bulgarian Academy of Sciences, in Sofia, Bulgaria. The study outlines the clinical development of Coriolus-MRL.

Finally, Professor Vittorio Calabrese (University of Catania, Italy) and Professor Tito Fernandes (Scientific Director, University of Lurio, Mozambique) propose to use mushroom nutrition in Alzheimer´s patients. This two-part proposal is focused on the premise that the HSV1 virus could trigger the biochemical events that lead to the development of Alzheimer´s disease. The paper relies on work conducted by researchers working with Dr. Frank M. LaFerla at the at the department of Neurobiology and Behavior at the university of California Irvine, in Irvine California and to work conducted by researchers working with Professor Ruth Itzhaki in the University of Manchester in the United Kingdom. As a first step, the proposed protocol seeks to verify that Coriolus-MRL when combined equally with Hericium-MRL can activate Lipoxin A4 (LXA4) activity which has been postulated as a novel approach to addressing the symptoms associated with Alzheimer´s disease. With confirmation that mushroom nutrition can activate LXA4 activity, then a small scale human study will be initiated.

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February'12


In this issue, Dr. Stoyan Borisov presents his clinical assessment study on the effect of Coriolus versicolor supplementation on patients with Low-risk and High-risk HPV subtypes. Dr. Chris Newton (Ph.D) proposes a study on the potential role of mushroom nutrition as modulators of toll receptor-mediated immune response.

The enzyme researcher, Dr. Amin Karmali (Ph.D) presents a detoxification analysis (in vitro) on mushroom nutrition, outlining the superoxide dismutase activity, cytochrome P450, cytochrome P450 reductase and secondary metabolites activity of Grifola frondosa (Maitake), Ganoderma lucidum (Reishi), Coriolus versicolor and Cordyceps sinensis.

Finally, the latest poster presentation on the efficacy of Coriolus versicolor in the treatment of HPV lesions (LSIL), presented by Dr. J.Silva Couto at the 14th World Congress of Cervical Pathology and Colpscopy- (IFCPC)-July 4th to 7th, 2011 in Rio de Janeiro, Brasil.

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August'09

In this issue two articles were submitted by a team of researchers based in the University of Catania (Italy) focused on the potential use of mushroom nutrition in neurodegenerative disease. The basis for hypothesis is due to the enzyme activity that offsets the reactive oxygen species associated with the onset of Parkinson’s, Alzheimer´s disease and ALS.

The articles are:
Mushroom Nutrition as a Target for Novel Therapeutic Strategies: Relevance to Nutritional Approaches and Antioxidant Redox Modulation in Ant-Ageing Medicine- Professor Vittorio Calabrese et al.

Comparative Enzyme Analysis of Polyporus umbellatus, Agaricus blazei, Pleurtous osteratus and Hericium erinaceus-Carolin Cornelius et al.

This issue closes with a poster presentation entitled:
Coriolus versicolor Supplementation as Immunonutrition in HPV Patients with Cervical Lesions (LSIL)-by Dr. Jose Silva Couto-Institute of Oncology, Coimbra Portugal.

The poster is an evaluation of the efficacy of Coriolus versicolor supplementation in patients infected with HPV with low-grade squamous intraepithelial lesions (LSIL). The article describes how Coriolus versicolor supplementation (3g /day) over a period of one year substantially increased regression of the dysplasia (LSIL) and induced clearance of the high risk sub-types of the HPV virus responsible for cervical cancer.

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March'07


The Clinical Journal of Mycology (formerly Mycology News) is dedicated to the dissemination of information on the clinical use of mushroom nutrition to health care practitioners. In this issue we address the role of Coriolus versicolor in the treatment of CIN-1 (LSIL HPV) and Herpes Simplex.

Dr J Silva Couto outlines the difference between LSIL and HSIL HPV and provides a protocol for use by medical professionals. In addition, Prof Amin Karmali explains the enzymatic qualities of Coriolus versicolor and how such attributes assist the immune system. Finally, Dr. Andrew French outlines his clinical experience using Coriolus versicolor in patients with herpes simplex with a recommended protocol for consultants.

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January'03

In this sixth edition, Dr Garth L. Nicolson outlines the link between Chronic Fatigue Syndrome, Fibromyalgia and other related conditions as well as the viruses associated with these respective conditions: Herpes Virus-6 (HHV-6), Cytomegalovirus (CMV). The Madrid based Nuria Lorite, pharmacist and TCM professor outlines a link between Chronic Fatigue Syndrome, Fibromyalgia and Rheumatoid Arthritis. In addition, the viral link between Epstein-Barr Virus (EBV) and fatigue related conditions such as Chronic Fatigue Syndrome, Myalgia Encephalitis, Fibromyalgia and Rheumatoid Arthritis are discussed. Finally, an article on the use of Cordyceps sinesis and Coriolus versicolor in athletes competing in triathlons is presented along with supplementation schedules.

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